《智能高分子材料的微结构修饰》冯传良，窦晓秋，徐亦斌|(epub+azw3+mobi+pdf)电子书下载

图书名称：《智能高分子材料的微结构修饰》

【作　者】冯传良，窦晓秋，徐亦斌

【丛书名】国家科学技术学术著作出版基金资助出版

【页 数】 183

【出版社】 上海：上海交通大学出版社 , 2021.11

【ISBN号】978-7-313-22099-8

【价 格】49.00

【分 类】智能材料-高分子材料-研究-英文

【参考文献】 冯传良，窦晓秋，徐亦斌. 智能高分子材料的微结构修饰. 上海：上海交通大学出版社, 2021.11.

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《智能高分子材料的微结构修饰》内容提要：

对外场有响应能力的智能合成材料是目前引起科研兴趣的新兴研究领域，也会面临许多大的挑战，但是高分子材料由于具有结构可设计性、功能可调的特点使其将来在开发基于智能高分子材料的生物材料、检测材料等方面显示出了巨大的潜力。因此，针对智能高分子及其潜在应用这一热点研究领域，本课程对研究生讲授介绍高分子材料，尤其酸碱响应性高分子材料的设计、制备、及其微纳米结构修饰等领域，包含未来的发展趋势等。以达到使学生对外场响应高分子合成制备、修饰及应用等有深刻的理解和认识，也为将来培养在该领域的研究和应用型人才做准备。具体的课程内容包括三大部分：微纳米结构制备的进展和现状；酸碱响应性高分子材料的制备、组装、修饰、表征等；微纳米结构修饰的智能高分子材料的未来发展及前景。

《智能高分子材料的微结构修饰》内容试读

Chapter 1

Reactive Platforms for Controllable

Fabrication of Functional (Bio)Interfaces

The aim of the fabrication of functional (bio)interfaces is to investigate interfacialreactions in confinement on stimuli-responsive homopolymer and diblock copolymerfilms,the immobilization of (bio)molecules,and the fabrication of biomolecularpatterns by reactive microcontact printing on these reactive polymer films.Takingadvantages of the microphase separation of diblock copolymer films,the fabricationof nanopatterns was investigated,which could contribute to the future developmentof a model system that enables one to area-selectively deposit (write)and address(read out)(bio)molecules.In this chapter,the scope of surface modification for(bio)reactive platforms and functional (bio)interfaces,chemical and topographicalpattern fabrication are introduced in detail.

1.1Scope of Surface Modification for (Bio)Reactive

Platforms and Functional (Bio)Interfaces

The objectives of biointerface research include investigations of properties of,andprocesses at,interfaces between synthetic materials on the one hand,and biolog-ical species and environments on the other hand.The discipline also includes thedesign and fabrication of biofunctional surfaces [1].Well-designed functional bioin-terfaces play an important role in biosensors and biochips for diagnostics,in medicalimplants in the human body,in tissue engineering,in bioelectronics,and inbiomimetic materials [2].For example,through investigating cell movement andspreading on tailored surfaces(biointerfaces),new insights into cell biology may beobtained [3],and new incentives for controlled drug delivery and also applicationsin the field of tissue engineering can be provided [4].The search for methods andformats (platforms)for the sensitive detection of biomolecular interactions,such ashybridization reactions between a biosurface-attached single-stranded catcher probeoligonucleotide and a complementary oligo-or poly-nucleotide strand from solution,

Shanghai Jiao Tong University Press 2021

C.Feng et al.,Microfabrication of Stimuli-Responsive Polymers,https:/doi.org/10.1007/978-981-33-6869-9_1

2

Chapter 1 Reactive Platforms for Controllable Fabrication...

currently attracts a lot of attention for a number of reasons,originating,e.g.,fromunsolved questions and problems in gene therapy [5].

In this context,convenient and reproducible surface modification procedures thatyield robust,functional biointerfaces are highly desirable.The requirements forobtaining such interfaces include,among others,the orientation-selective immo-bilization(conjugation)of biomolecules,such as receptors,antibodies,and proteins,the retention of the biological activity of these immobilized biomolecules,the control(elimination)of non-specific biomolecule (e.g.,protein)adsorption,high molecularloading in bio-available configurations,the control of intermolecular distances in thesubstrate normal direction,defined mechanical properties of underlying substrates,as well as the control of roughness and topographical structures,patterns,etc.

Self-assembled monolayer (SAM)approaches [6],which can producemonomolecular films,have been used to immobilize biological molecules on avariety of substrates.SAMs have also been successfully used for the developmentof (in vitro)biosurfaces that can,for instance,mimic naturally occurring molecularrecognition processes due to the structural and compositional control in SAMs withalmost molecular precision [7].However,a number of inherent characteristics,suchas environmental stability [8],and also the absence of independent control of chem-ical and topographical patterns together with variable substrate moduli,as deemedcrucial for cell-surface interaction studies [9],impose limitations for their applica-tion,e.g.,in studies of cell-surface interactions.Similarly,the molecular loading ofthese 2-D systems is limited and thus impairs the development of new highly sensitivebiosensors.

As an alternative,the deposition of polymeric materials onto solid substratesreceives increasing attention [10].Compared with SAMs,polymeric thin films havebeen shown to possess a number of important advantages,such as robustness andstability,and the unique possibility to introduce simultaneously topographic andchemical (compositional)patterns that span the 100 um to sub-100 nm regime,aswell as their defined mechanical modulus for various application areas [9].Thin filmsbased on polymers that incorporate reactive functional groups also provide a quasi3-D geometry which can be further modified by chemical reactions with biomoleculesand thereby overcome the mentioned intrinsic limitations of SAMs [11].

1.2Chemical and Topographical Pattern Fabrication

from Micrometer to Nanometer Length Scales

Truly functional biointerfaces call for advanced design and preparation in order tomatch the sophisticated recognition ability of biological systems,which include thecontrol of chemical composition on length scales spanning the 100 um to sub-100 nmregime.Specifically,combined topographic and chemical patterns on surfaces arerequired in order to match typical spacings of proteins on the nanometer scale andentire cells at the 10-100 um scale.For example,it is found that the distance

1.2 Chemical and Topographical Pattern Fabrication...

between RGD [12]functionalized cell-adhesive dots on the nanometer scale maydetermine cell attachment and spreading on patterned surfaces.These effects havebeen attributed to the corresponding cellular responses to restricted integrin clusteringrather than the insufficient number of ligand molecules in the cell-matrix interface [13].

Current developments to miniaturize patterns rely on"top-down"techniques,suchas photolithography [14]and soft lithography [15-17].Among these techniques,microcontact printing (uCP)is one of the promising approaches for producing(bio)chemical patterns on various solid substrates.In applications,the developmentof certain biosensors [18],the simplicity of the method,the low cost,the flexibility,the possibility to pattern curved substrates,etc.make uCPa very attractive techn-ique to fabricate chemical patterns.Alternative routes have also been opened byunconventional techniques [19],such as microwriting [20],micromachining [21],and dip-pen nanolithography [22].

It has been realized that the requirement to create patterns in 10-100 nm range forfuture applications is also highly relevant in many other fields outside the bionano-ornano-biotechnology area.These areas include,among others,electronics [23],analyt-ical chemistry [24],and preparation of nanoarrays [25],where the large-scale,routineformation of nanometer-sized structures remains a challenge that limits advances inmany fields of nanotechnology.

In this sense,"bottom-up"self-assembly approaches are becoming increasingly aviable tool for nanofabrication.In these approaches,the controlled,yet spontaneousassembly of complex structures of nanometer dimensions starting from molecularbuilding blocks is being exploited.Among the various promising materials,blockcopolymers are widely considered as ideal precursors for the formation of orderedorganic,but also inorganic [26]structures.

In particular,the nanometer scale patterns obtained from block copolymer filmscan be potentially used to spatially control the deposition of biomolecules in the future(Scheme 1.1),which can be critical for fundamental biological research involvingcell biology [27]and for a number of applications,such as high-throughput genomicarrays and combinatorial library screening [28].

In the envisioned combined bottom-up/top-down approach,the self-assembly ofblock copolymers and the encoded information regarding domain spacing and peri-odicity,as well as distinct chemical functionality,would be exploited in conjunctionwith,e.g.,advanced scanning probe microscopy-based lithography approaches forcontrolling the local chemical composition of ordered 2-D arrays on the 10-100 nm scale.

100nm

site-specific

derivatization

analysis

●)

Scheme 1.1 Schematic of a block copolymer-based nanoperiodic array,which can be derivatized atpredefined sites and analyzed to yield chemical/compositional information after a screening reaction

Chapter 1 Reactive Platforms for Controllable Fabrication...

Based on the full control of surface chemistry and interfacial organic coupling chem-istry on these polymer-derived platforms,array-based screening formats with ultra-high information contents,as well as tailored biointerfaces for cell-surface studieswould become possible in the long run.

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