《中医与西医 对抗过敏性疾病》李秀敏，亨利·欧利希原著|(epub+azw3+mobi+pdf)电子书下载

图书名称：《中医与西医 对抗过敏性疾病》

【作　者】李秀敏，亨利·欧利希原著

【页 数】 214

【出版社】 南京：东南大学出版社 , 2019.01

【ISBN号】978-7-5641-8011-9

【价 格】48.00

【分 类】变态反应病-中西医结合疗法

【参考文献】 李秀敏，亨利·欧利希原著. 中医与西医 对抗过敏性疾病. 南京：东南大学出版社, 2019.01.

图书封面：

图书目录：

《中医与西医 对抗过敏性疾病》内容提要：

本书介绍了李秀敏教授及其团队的实验及治疗过程以及诸多成功治愈过敏性疾病的病例。对于中国的医学从业人员及学者来说，提供了中西医结合治疗诸多过敏性疾病的典型病例，也期待中国的医学从业人员能够在各自的学术和实践活动中发扬光大传统医学，融合中西医之长，为更多的患者带来福音。

《中医与西医 对抗过敏性疾病》内容试读

Chapter 1

第一章

FOOD ALLERGY

食物过敏

Some chimpanzees,when infected with intestinal

一些黑猩猩在感染肠道寄生

parasites,eat bitter,foultasting plants,which they

虫时，就会吃发苦难闻的植物，这

otherwise avoid and which contain biologically active

些植物要么能使它们避免受到感

compounds that kill intestinal parasites(Joseph Narby,

染，要么含有能杀死肠道寄生虫的

The Cosmic Serpent:DNA and the Origins of Knowledge,

生物活性化合物。（约瑟夫·纳

1998).

比，《宇宙之蛇：DNA和知识的起

源》，1998)

I like this passage for a couple of reasons.One is

我喜欢这篇文章出于几个原因。

that it shows how basic the impulse to use vegetation as

一是它显示了把植物当作药物的基

medicine is.TCM has thousands of years of recorded

本动机。中医有文字记载的历史已

history,and clearly it did not begin with the

有千年，显然它不是始于文明的源

beginnings of civilization,and it did not even start

头，甚至也不是和人类一起开始的。

with humanity.The other is that it shows how

另一方面，它显示了发生在动物与寄

fundamental the batde is between animals and

生虫这些大自然勒索者之间的战争

parasites,nature's extortionists.Chimps knew these

是多么重要。黑猩猩知道这些小东

little things were bad for them even if they could not

西对它们不利，即使看不到它们或者

see them or imagine them.They knew they were sick

无法想象它们的样子。它们知道自

and they tried to do something about it.Readers of

己病了，于是想办法解决。我写的另

my other book about Dr.Li,Food Allergies:

一本关于李医生的书《食物过敏：中

Traditional Chinese Medicine,Western Science,and

医，西方科学和治愈研究》的读者知

the Search for a Cure know that her explorations for a

道，她对食物过敏治疗的探索始于

food allergy treatment began with something called

种叫作乌梅丸的中药，这是一种古老

Wu Mei Wan,an old remedy for these worms that

的可以治疗蠕虫的药，这种蠕虫以人

feed off people,weakening them without killing

为食，不断消耗人的体能而不杀死

them,except for children who may not have time to

人，当然自身防御系统还没有发育完

develop their own defenses.In a body battling

善的儿童除外。人体在对抗寄生虫

parasites,IgE and eosinophils are powerful defenses,

时，免疫球蛋白E及嗜酸性粒细胞

Traditional Chinese Medicine,Western Science,and the Fight Against Allergic Disease

中医与西医：对抗过敏性疾病

but in our morehygienic society,they pick on the

构成强大的防御系统，但在我们这个

wrong targets and become our enemies.

卫生状况日益进步的社会，它们会选错目标，成为我们的敌人

It is a case of mistaken identity.Certain peanut

这是一个错误识别的例子。某

proteins are very similar to those found in helminths,

些花生蛋白与螨虫体内俗称寄生虫

commonly known as parasitic worms.Likewise

的蛋白非常类似。同样，尘螨和蟑螂

proteins found in dust mites and cockroaches,which

体内的蛋白是强有力的环境过敏原，

are potent environmental allergens,are similar to some

类似于虾和龙虾这些主要的食物过

found in shrimp and lobster-major food allergens.

敏原中发现的蛋白。李医生研究食

The great moment of revelation came when Dr.Li was

物过敏反应的时侯也是发现真相的

studying food allergy reactions and it dawned on her

伟大时刻。她突然意识到这些反应

that it sounded like parasites so she dipped into the

听起来像是寄生虫所为，于是她沉下

TCM trove Classic Formulas and Strategies and came

心来钻研中医古籍《经方要略》，并

up with Wu Mei Wan.As readers will also recall,in提出了鸟梅丸配方。读者还会记得，trying to decide how to deliver this medicine to

在试图决定如何把这个药送达患者

patients,Dr.Li's colleagues tasted it in the form of

时，李医生的同事们就像在中国一

brewed tea,as it would be taken in China.They

样，把药以沏茶的方式进行品尝，结

unanimously agreed that they could not stand the taste.

果一致认为无法忍受这种味道。

When I finished writing the other book,the Phase

在我写完另一本书，《食物过敏

II trial of Food Allergy Herbal Formula-2 FAHF-2),

植物药配方2(FAHF-2)的二期临床

the successor to Wu Mei Wan,was still in a state of

试验》，鸟梅丸处方的改良版，仍处

equipoise.That is,the work was done but the data had

于平衡状态。也就是说，工作已完

not been compiled or interpreted or published.

成，但数据尚未汇编、解释或发布。

To recap,this double-blind,randomized,

总的来说，这项双盲、随机、安慰

placebo-controlled study enrolled 68 subjects,12-45

剂对照研究征集了68名12一45岁

years of age,with allergies to peanut,tree nut,

的受试者，包括对花生、坚果、芝麻

sesame,fish,and/or shellfish.Food allergies for all

鱼和/或贝类过敏。所有研究参与者

study participants were confirmed at the outset by a

的食物过敏一开始就通过严格的双

stringent double-blind,placebo controlled food

盲、安慰剂对照食物激发试验

challenge (DBPCFC).Forty-six received FAHF-2 and 22

(DBPCFC)已确认。46人接受

placebo.After six months of therapy,subjects underwent

FAHF-2,22人接受安慰剂治疗。在

another DBPCFC.For those who demonstrated increases

六个月的治疗之后，受试者接受了另

in eliciting dose,a repeat challenge was performed three

一个双盲、安慰剂对照食物激发试验

2

Chapter 1 FOOD ALLERGY

第一章食物过敏

months after stopping therapy.

(DBPCFC)。对那些显示诱导剂量

增加的患者，在停止治疗三个月后再进行一次食物激发试验。

The results were disappointing to hopeful food

结果对那些对食物过敏治疗充

allergy parents.There was no clinical breakthrough

满希望的父母来说是令人失望的。

from this study.However,the laboratory results do

这项研究没有取得临床突破。然而，

suggest positive immune modulation is possible with

实验结果确实表明FAHF-2可能具有

FAHF-2.Immunological studies of the subjects'

积极的免疫调节作用。对临床受试

PBMCs peripheral blood mononuclear cells)drawn at

者基于基础数据并用FAHF-2和食物

baseline and incubated with FAHF-2 and food allergen

过敏原培养的外周血单个核细胞

produced significantly less IL-5,greater IL-10 and

(PBMC)的免疫学研究可见，PBMCs

increased numbers of Tregs than untreated cells-a

明显产生较少的L-5、更多的L-10,

shift away from the allergic Th2-dominant cytokines.

并增加了Tregs细胞的数量，这与未

经处理的细胞相比，过敏性T2主导

的细胞因子变化很大。

While the subjects'cells tested in the lab outside

当受试者的细胞在体外的实验

of their bodies showed benefit with FAHF-2 treatment,

室测试中显示FAHF-2治疗有效时，

what happened with the subjects themselves?It turns

这些受试者自身发生了什么？结果

out that 44%had trouble sticking with the protocol.

发现，44%的人在遵守疗法方面有困

The real numbers of non-compliant subjects may have

难。不符合规定的受试者的真实数

been higher,but the count was taken according to how

量可能会更高，但数据记录是根据研

many pills were returned at the conclusion of the study

究结束时退回的药丸数量多少而定。

period.Even more pills may still be sitting in medicine

甚至还会有更多的药丸放在受试者

cabinets in subjects'homes.

家中的药箱里。

As with most studies,in retrospect,there seem to

回想起来，和大多数研究一样

have been holes in the design.This do not mean that

设计上似乎也存在漏洞。这并不意

FAHF-2 cannot work in humans.It was asking a great

味着FAHF-2在人类身上不起作用。

deal for nearly 70 individuals ranging in age from 12,

它要求从12岁到大学生再到中年将

D Julie Wang,MD,FAAAAI:Stacie M.Jones,MD;Jacqueline A.Pongracic,MD.FAAAAI:Ying Song,MD:Nan

Yang,PhD:Scott H.Sicherer,MD:Melanie M.Makhija,MD,MS:Rachel Glick Robison,MD;Erin Moshier,MS;

James Godbold,PhD:Hugh A.Sampson,MD;Xiu-Min Li,MD,MS,"Safety,clinical and immunologic efficacy of a

Chinese herbal medicine (FAHF-2)for food allergy,"Journal of Allergy and Clinical Immunology 2015;135(2).

Supplement:AB234.

3

Traditional Chinese Medicine,Western Science,and the Fight Against Allergic Disease

中医与西医：对抗过敏性疾病

where they would have at least been subject to some

近70人，每天每餐吞下10粒药丸，

element of maternal supervision,through college age

即每天30粒药丸。年龄在12岁的

and into middle age to swallow 10 pills at each of three

至少要在母亲的监督下服用。他们

meals during the day,i.e.,30 pills per day.They had

必须把他们中午的药打包以便午餐

to remember to pack their noon dose to be taken at

时服用。严格的药物治疗方案在母

lunch.Strict medication regimens are best practiced

亲的监控下才能最好地执行。此外，

under the watchful eye of mothers.Moreover,six

免疫系统要产生大规模的重建，6个

months is a very short period of time to effect a

月还为时过短。在李医生的临床实

wholesale renovation of the immune system.In her

践中，她的治疗项目周期为24年，

clinical practice,Dr.Li projects 2-4 years duration

所以6个月时间只是一瞬而已。

for treatment,so six months is a drop in the bucket.

According to Dr.Li,

There are still a lot of things to learn from this

从这项实验中我们还有很多

trial.We think the product itself needs to be improved-

东西要学，我们认为产品本身需

if we can reduce the number of pills we can increase

要改进一如果我们可以减少药

compliance and optimise the product.

丸数量，我们就可以提高药品合规性并优化产品

We have identified a number of bio-active

我们已经鉴定了许多生物活

compounds and are able to detect the concentrations of

性化合物，并能够检测血液和尿

the compounds in blood and urine.This method will be

液中化合物的浓度。这种方法将

an important means of assessing adherence.We began

是评估依从性的重要手段。我们

to generate preliminary data using this technology.We

开始使用这种技术来生成初步数

need to test more work before drawing definitive

据。在我们得出明确结论之前我

conclusions.The preliminary data showed that the

们要对数据做更多的检验。初步

compliance rate is lower than 50%,but we have to

形成的数据显示依从率低于

figure out if it is a true compliance issue or the Gl

50%,但我们必须要弄清楚它是否

absorption or metabolism issues.

是一个真正的依从问题还是胃肠吸收或代谢问题

Interestingly,the preliminary data showed that if

有趣的是，初步数据表明如果

the individuals showed high enough blood concentration

个体生物活性化合物标记的血液

of the bioactive compound marker,this individual

浓度显示足够高，则该个体就会显

showed good clinical outcomes.This supports our in

示良好的临床效果。这支持了我

vitro study data,which shows when human immune cells

们的体外研究数据，当人的免疫细

are directly exposed to EAHF-2 extract there are

胞直接接触EAHF-2提取物时，对

Chapter 1 FOOD ALLERGY

第一章食物过敏

beneficial immune modulatory effects.There are gaps of

人的免疫调节是有积极影响的。

knowledge between TCM human use experience,in vivo

在中医药实验研究、动物体内模型

animal model study,human in vitro study,and then

研究、人体体外研究以及最后的人

finally to human in vivo study trials.Our continued work

体体内研究试验之间都存在认知

will help us fill in the gaps.

差距，我们接下来的研究工作将有助于填补这些差距。

In the earlier book,I described the creation of a

在前面的书中，我描述了FAHF

refined form of FAHF-2,which employs butanol (B-

2的提炼方法，它使用正丁醇(B

FAHF-2)to separate the active ingredients from the

FAHF-2)从惰性成分中分离活性成

inert ones.The FDA has approved use of B-FAHF-2

分。美国食品药品监督管理局

for further experiments without having to go back to

(FDA)已经批准使用B-FAHF-2进

square one with murine models and early-phase human

行进一步的实验，而不必回到小鼠模

trials.

型和早期人类试验的起点。

The test tube indicators are encouraging.Dr.Li

试管实验得出的指标令人鼓舞。

says,

李医生说：

For several years we have been looking at which

几年来，我们一直在观察哪

herb compounds affect IgE.We have demonstrated that

些草药化合物影响IgE(免疫球蛋

human memory B-cell lines that produce IgE could

白E)。我们已经证明，产生IgE

remain very high,even if they are not stimulated.You

的人类记忆B细胞系即使不被刺

put them in a good nutrition medium and they will grow

激也可以保持非常高的水平。你

and produce IgE.In a 2014 study we compared effects

把它们放在一个好的营养培养基

of FAHF-2 and B-FAHF-2 on IgE production.Both

里，它们就会生长并产生gE。在

significantly reduced IgE,but B-FAHF-2 requires nearly

2014年的一项研究中，我们比较

nine times less concentration

了FAHF-2和B-FAHF-2对IgE产生的影响。两者都使gE显著降

低，但B-FAHF-2需要的浓度低于

FAHF-2近9倍

We also screened the nine herbs from B-FAHF-2

我们还筛选了B-FAHF-2中

and found three of them directly suppressed IgE.Other

的九味中药，发现其中3种直接抑

herbs have no direct effect on IgE,but some of them

制1gE。其他药物对IgE没有直接

suppress inflammation and histamine release while

影响，但其中一些药物抑制炎症和

others enhance protective immune responses such as

组胺释放，而另一些药物会增强保

IgG.But this study only focused on identifying the

护性免疫反应，如IgG。但本研究

constituents in vitro that we focused on one of the IgE

仅集中在体外的成分鉴定，其中关

5

Traditional Chinese Medicine,Western Science,and the Fight Against Allergic Disease

中医与西医：对抗过敏性疾病

inhibitory herbs and identified the active compounds in

注的是一种抑制【gE的药物成分，

vitro.

并在体外鉴定其活性成分。

2500

100

1C50=316.6μg/mL

2000

(qw/Bu)g3

500

率米

50

000

500

3162125250500

FAHF-2(μg/mL)

FAHF-2(ug/mL)

(a)

b

100

3000

1C50=-32.76g/mL

水率米

1000

米米*

0

0

7.5153060120

0

7.5153060

120

B-FAHF2(ug/mL)

B-FAHF-2(μg/mL

(c)

(d)

B-FAHF-2 inhibited IgE production by human memory B cells (U266 cells)at nearly 10 times lower IC50concentration.

Yang et al.Ann Allergy Asthma Immunol.2014

B-FAHF-2 More Potently Inhibited IgE Production than FAHF-2 in vitro

B-FAHF2在试管内比FAHF-2更能抑制IgE的产生

One of the things that make this avenue of

使得这条研究之路成为令人兴

research so exciting is that it holds out the possibility of

奋的事情之一是，在免疫机制下它拥

making long-term changes in the underlying immune

有长期变化的可能性。过敏反应是

mechanisms.Allergic responses are "amnestic"

可被记忆的“缺失”。病人可以很多

remembered.A patient can go years with no exposure

年在没有接触过敏原情况下好好的，

to an allergen and then respond violently.It is this

然后一旦再接触便产生强烈反应。

tendency that makes "avoidance"a dirty word in the

正是这种倾向使得“回避”这一污浊

food allergy community.

词汇出现在食物过敏分类里。

As Dr.Li says,

正如李医生所说，

Memory cells do not need a strong stimulus.

记忆细胞不需要强刺激，有

sometimes none at all.Most of the time they settle in the

时根本不需要。大多数情况下，

bone marrow where they wait until they are ready to

它们会在存在于骨髓中，直到它

produce IgE.We discovered the compound that

们准备好产生IgE。我们发现了

6

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